Perbedaan Kadar Brain Derived Neurotropic Factor Neonatus Dari Ibu Hamil Normal Dan Anemia Defisiensi Besi



Ainal Mardiah, Arni Amir, Andi Friadi, Ellyza Nasrul

Abstract


Iron deficiency anemia is anemia caused by iron deficiency in the blood. Maternal iron deficiency affects the low iron reserves in neonates and it also influences on Brain Derived Neurotropic Factor (BDNF)  which affects cognitive function. The purpose of this study was to determine the difference mean of BDNF in neonates from normal pregnant women and pregnant women with iron deficiency. The design of this research was Cross Sectional design. This research was conducted in Community Health Center of Lubuk  Buaya, Ambacang Community Health Center, Community Health Center of Ikur Koto Health Center and Biomedical Laboratory of Andalas University on February 2017 to April 2018. There were 42 pregnant women was selected as sample e of this research. The samples were chosen by Consecutive Sampling. Then, the sample is divided into two groups: normal pregnant women and pregnant women with iron deficiency anemia. BDNF are examined by the ELISA. Next, the data were analyzed by using T test. The levels of BDNF neonates in normal pregnant group was 3.65(ng/ml) and the anemia pregnant group was 1.74(ng/ml) (p <0.05). There was significant difference of BDNF levels in neonates from normal pregnant women and pregnant women with iron deficiency anemia. The conclusion of this study is there is a difference of average BDNF in neonates from normal pregnant women and pregnant women with iron deficiency.

 

Anemia defisiensi besi adalah anemia yang disebabkan karena kekurangan zat besi dalam darah. Defisiensi besi  maternal berdampak pada rendahnya cadangan besi pada neonatus dan berdampak terhadap ekspresi Brain Derived Neurotropic Factor (BDNF) yang berpengaruh pada fungsi kognitif. Tujuan penelitian ini adalah untuk mengetahui perbedaan rerata kadar BDNF pada neonatus dari ibu hamil normal dan ibu hamil defisiensi besi. Desain penelitian ini adalah Cross Sectional. Penelitian dilakukan di Puskesmas Lubuk Buaya, Puskesmas Ambacang, Puskesmas Ikur Koto dan Laboratorium Biomedik Universitas Andalas pada bulan Februari 2017 – Juli 2018. Sampel Penelitian adalah ibu hamil sebanyak 42 orang yang dipilih secara Consecutive Sampling, sampel dibagi menjadi dua kelompok yaitu ibu hamil normal dan ibu hamil anemia defisiensi besi. BDNF diperiksa dengan metode ELISA. Data dianalisa menggunakan uji T test. Kadar BDNF neonatus pada ibu kelompok normal adalah 3,65(ng/ml) dan kelompok ibu anemia adalah 1,74(ng/ml) (p<0,05). Terdapat perbedaan bermakna kadar BDNF pada neonatus dari ibu hamil normal dan ibu anemia defisiensi besi.


Keywords


Iron Deficiency Anemia; Brain Derived Neurotropic Factor

Full Text:

PDF

Article Statistics

Abstract View : 0 Times
PDF : 0 Downloaded

References


Brunette, K. E., Tran, P. V., Wobken, J. D., Carlson, E. S., & Georgieff, M. K. (2010). Gestational and neonatal iron deficiency alters apical dendrite structure of CA1 pyramidal neurons in adult rat hippocampus. Developmental Neuroscience, 32(3), 238–248. https://doi.org/10.1159/000314341

Masrizal. (2007). Anemia Defisiensi Besi. Jurnal Kesehatan Masyarakat, II(1), 140–145.

Mireku, M. O., Davidson, L. L., Boivin, M. J., Zoumenou, R., Massougbodji, A., Cot, M., & Bodeau-Livinec, F. (2016). Prenatal Iron Deficiency, Neonatal Ferritin, and Infant Cognitive Function. Pediatrics, 138(6), e20161319–e20161319. https://doi.org/10.1542/peds.2016-1319

Radlowski, E. C., & Johnson, R. W. (2013). Perinatal iron deficiency and neurocognitive development. Frontiers in Human Neuroscience, 7(September), 1–11. https://doi.org/10.3389/fnhum.2013.00585

Sari, M., Bloem, M. W., & Semba, R. D. (2014). among families in Indonesia, 16(9), 1913–1925. https://doi.org/10.1007/s10995-011-0938-y.Relationship

Shao, J., Lou, J., Rao, R., Georgieff, M. K., Kaciroti, N., Felt, B. T., … Lozoff, B. (2012). Maternal Serum Ferritin Concentration Is Positively Associated with Newborn Iron Stores in Women with Low Ferritin Status in Late Pregnancy. Journal of Nutrition, 142(11), 2004–2009. https://doi.org/10.3945/jn.112.162362

Subedi, L., Huang, H., Pant, A., Westgate, P. M., Bada, H. S., Bauer, J. A., … Sithisarn, T. (2017). Plasma Brain-Derived Neurotrophic Factor Levels in Newborn Infants with Neonatal Abstinence Syndrome. Frontiers in Pediatrics, 5(November), 1–7. https://doi.org/10.3389/fped.2017.00238

Tran, P., & Carlson, E. (2008). Early-life iron deficiency anemia alters neurotrophic factor expression and hippocampal neuron differentiation in male rats. The Journal of Nutrition, 138(August), 2495–2501. https://doi.org/10.3945/jn.108.091553.2495

Allen LH. (2007). Anemia and Iron Deficiency: Effect on Pregnancy Outcome. Am Jour Clin Nutr:71(5): 1280S – 1284S.

Arisman. (2009). Gizi dalam Daur Kehidupan. Jakarta: EGC.

Bathina, S., Undurti, N. (2014) . Brain Derived Neurotrophic Factor and Its Clinical Implications. USA: UND Life Science.

Brunette K.E., Tran P.V., Wobken JD., Carlson E.S., and Georgieff M.K. ( 2010 ). Gestational and Neonatal Iron Deficiency Alters Apical Dendrite Structure of CA1 Pyramidal Neurons in Adult Rat Hippocampus. USA : Minnesota

Cunningham, F G., dkk. (2005). Obstetri Williams Volume I. Jakarta : EGC

Dahlan, MS. ( 2013 ). Besar Sampel dan Cara Pengambilan Sampel Dalam Penelitian Kedokteran dan Kesehatan. Jakarta : Salemba Medika.

Dallman,P.R. (1990). Progress in the Prevention of Iron Deficiency in Infants. International Life Sciences Institute (ILSI) Press , pp. 241-250

Dinas Kesehatan Kota Padang. (2016). Profil Kesehatan Kota Padang Tahun 2015. Padang: Dinas Kesehatan Kota Padang

Estrada Jose A, Contreras Irazu, Riveri F Bernardo Pliego, Otero Gloria A. ( 2014 ). Review Molecular Mechanism of Cognitive Impairment in Iron Deficiency: Alterations in Brain Derived Neurotrophic Factor and Insulin Like Growth Factor Expression and Function in The Central Nervous System . Nutritional Neuroscience, vol 17 no 5.

Fairbanks V F,Beutler E. Iron Metabolism. In: Beutler et aL, EDITORS William Hematology. New York : Mc Graw – Hill inc ; 2011.

Georgief Michael K MD. ( 2008). The Role of Iron In Neurodevelopment: Fetal Iron Deficiency and The Developing Hippocampus. Biochem Soc Trans: 36: 1267-1271.

Herbert V. (1992). Everyone Should Be Tested for Iron Disorder. J Am Diet Assoc: 1502

International Nutritional Anemia Consultative Group Symposium.(2004). Iron Deficiency in Early Life: Challenges and Progress.

Jakarta : EGC.

Karasahin, E., Ceyhan, S. T., Goktolga, U., Keskin, U. & Baser, I. (2006) Maternal Anemia and Perinatal Outcome. Perinatal Journal, 15(3).

Kementrian Kesehatan RI. (2013). Riset Kesehatan Dasar. Jakarta: Kementrian Kesehatan RI.

Kementrian Kesehatan RI. (2014). Profil Kesehatan Indonesia. Jakarta: Kementrian Kesehatan RI.

Lozoff Betsy, MD and Georgieff Michael K .(2006). Iron Deficiency and Brain Development. Seminar In Pediatric Neurology ; 13:158-165

Manuaba. (2010). Ilmu Kebidanan Pemyakit Kandungan dan Keluarga Berencana. Jakarta : EGC

Masrizal. (2007). Anemia Defisiensi Besi. Jurnal Kesmas Andalas, vol 2 no 1.

Muhammad, A., Sianipar, O.( 2005). Penentuan Defisiensi Besi Anemia Penyakit Kronis Menggunakan Peran Indeks sTfR-F. Yogyakarta : PKUGM

Nitin S. (2003). Change In Neurotropin Levels In Umbilical Cord Blood From Infants With Different Gestational Ages and Clinical Conditions. Division of Neonatology Department of Pediatrics

Proverawati, A. (2011). Anemia dan Anemia Kehamilan. Yogyakarta: Nuha Medika

Radlowski EC, Johnson RW. (2013). Perinatal Iron Deficiency and Neurocognitive Development. Front Hum Neuroscience Sept ;7:585

Rajab, Wahyudin. (2009). Buku Ajar Epidemiologi Untuk Mahasiswa Kebidanan.

Rao. (2007). Iron in Fetal and Neonatal Nutrition. Division of Neonatology University of Minnesota

Ringoringo, HP. (2009). Insiden Defisiensi Besi dan Anemia Defisiensi Besi pada Bayi Berusia 0-12 Bulan di Banjarbaru Kalimantan Selatan: Studi Kohort Prospektif. Sari Pediatri :Vol 11 No 1.

Saifuddin, A., B. (2008). Buku Acuan Nasional Pelayanan Kesehatan Maternal Dan Neonatal.Jakarta : Yayasan Bina Pustaka Sarwono Prawirohardjo

Sastroasmoro, S. Ismael, S. (2014). Dasar – Dasar Metodologi Penelitian Klinis Edisi Ke 5. Jakarta: Sagung Seto

Simanjuntak. (2008). Hubungan Anemia pada Ibu Hamil dengan Kejadian BBLR di BP RSU Rantaurapat. Tesis. Universitas Sumatra Utara.

Wibowo N, Regina Purba RT. Anemia Defisiensi Besi dalam Kehamilan. Dexa Media, Jan- Maret 2006;19(1)

Winkjosastro, H.Saifudin, AB. Rahimhadhi, T. (2008). Ilmu Kebidanan. Jakarta: Yayasan Bina Pustaka Sarwono Prawirohardjo.

World Health Organization. (2011). Haemoglobin Concentrations for The Diagnosis of Anaemia and Assessment of Severity.

World Health Organization. (2012). Global Nutrition Target 2025 Anemia Policy Brief. Diakses pada tanggal 3 Juli 2015 dari, www.who. int/entity/nutrition/publications/globaltargets2025_policybrief _ anaemia/en/ - 29k.




Copyright (c) 2018 Ainal Mardiah, Arni Amir, Andi Friadi, Ellyza Nasrul

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Published by Lembaga Layanan Pendidikan Tinggi (LLDIKTI) Wilayah X

Khatib Sulaiman Street Padang
West Sumatera
Phone: +62751705637
Fax: +62751705637
Email: [email protected]

E-ISSN : 2477-6521